Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase
نویسندگان
چکیده
منابع مشابه
All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity.
Sphingomyelin synthase-related protein (SMSr) synthesizes the sphingomyelin analog ceramide phosphoethanolamine (CPE) in cells. Previous cell studies indicated that SMSr is involved in ceramide homeostasis and is crucial for cell function. To further examine SMSr function in vivo, we generated Smsr KO mice that were fertile and had no obvious phenotypic alterations. Quantitative MS analyses of ...
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The sphingolipids are a diverse family of lipids with important roles in membrane compartmentalization, intracellular signaling, and cell-cell recognition. The central sphingolipid metabolite is ceramide, formed by the transfer of a variable length fatty acid from coenzyme A to a sphingoid base, generally sphingosine or dihydrosphingosine (sphinganine) in mammals. This reaction is catalyzed by ...
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We investigated the possibility of the proapoptotic lipid ceramide as an indicator of chemoresistance in leukemia. Doxorubicin (DOX) increased the ceramide level and apoptosis in drug-sensitive HL-60 cells but not in drug-resistant HL-60/ADR cells, under the condition that the uptake of DOX was not different between the two cell lines. In addition, exogenous N-acetylsphingosine (C2-ceramide) en...
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In their review of sphingolipids as regulators of cell function, Y. A. Hannun and R. M. Bell (1) discuss the hypothesis that some of the reactions involved in sphingolipid metabolism may regulate protein kinase C (PKC) activity through the generation or removal of PKC-inhibiting metabolites. An important addition to the pathways considered in (1) is the reaction catalyzed by phosphatidylcholine...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2009
ISSN: 0022-2275
DOI: 10.1194/jlr.m900230-jlr200